Longitudinal Community Walking Activity in Duchenne Muscular Dystrophy.
| Title | Longitudinal Community Walking Activity in Duchenne Muscular Dystrophy. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Fowler EG, Staudt LA, Heberer KR, Sienko SE, Buckon CE, Bagley AM, Sussman MD, McDonald CM |
| Journal | Muscle Nerve |
| Volume | 57 |
| Issue | 3 |
| Pagination | 401-406 |
| Date Published | 2018 03 |
| ISSN | 1097-4598 |
| Keywords | Adolescent, Child, Child, Preschool, Disease Progression, Gait, Humans, Male, Muscular Dystrophy, Duchenne, Walking |
| Abstract | INTRODUCTION: Natural history studies for Duchenne muscular dystrophy (DMD) have not included measures of community ambulation. METHODS: Step activity (SA) monitors quantified community ambulation in 42 boys (ages 4-16 years) with DMD with serial enrollment up to 5 years by using a repeated-measures mixed model. Additionally, data were compared with 10-meter walk/run (10mWR) speed to determine validity and sensitivity. RESULTS: There were significant declines in average strides/day and percent strides at moderate, high and pediatric high rates as a function of age (P < 0.05). Significant correlations for 10mWR versus high and low stride rates were found at baseline (P < 0.05). SA outcomes were sensitive to change over 1 year, but the direction and parameter differed by age group (younger vs. older). Changes in strides/day and percentages of high frequency and low frequency strides correlated significantly with changes in 10mWR speed (P < 0.05). DISCUSSION: Community ambulation data provide valid and sensitive real-world measures that may inform clinical trials. Muscle Nerve 57: 401-406, 2018. |
| DOI | 10.1002/mus.25743 |
| Alternate Journal | Muscle Nerve |
| PubMed ID | 28692198 |
